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Autophagic Punctum

Rapamycin inhibits mTORC1, but not completely

Carson C. Thoreen and David M. Sabatini
Volume 5, Issue 5
July 1, 2009
Pages 725 - 726
DOI: 10.4161/auto.5.5.8504

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Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.

Punctum to: Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS. J Biol Chem 2009; 284:8023–32; PMID: 19150980; DOI: 10.1074/jbc.M900301200.


Authors

Carson C. Thoreen
Whitehead Institute for Biomedical Research; Department of Biology; Cambridge, MA USA
David M. Sabatini Corresponding author: sabatini@wi.mit.edu
Whitehead Institute for Biomedical Research; Department of Biology; Cambridge, MA USA

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