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Review Series: Autophagy in Higher Eukaryotes - A Matter of Survival or Death
The selectivity of autophagy and its role in cell death and survival
Li Yu, Lindsey Strandberg and Michael J. Lenardo
Volume 4, Issue 5July 1, 2008
Pages 567 - 573
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Autophagy is a cellular process whose primary function is to degrade long-lived proteins and recycle cellular components. Beside macroautophagy, there are several forms of selective autophagy, including chaperone-mediated autophagy (CMA), cytoplasm to vacuole targeting (Cvt), pexophagy, and mitophagy. In this review, we summarize what is currently known about selective autophagy, and discuss its role in cell death and survival. We also discuss possible mechanisms underlying the selectivity of macroautophagy.
Authors
- Li Yu
- National Institute of Allergy and Infectious Diseases
- Lindsey Strandberg
- National Institute of Allergy and Infectious Diseases
- Michael J. Lenardo
- National Institute of Allergy and Infectious Diseases
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF
If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.
