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Article Addendum

Targeting the Weak Point of Cancer by Induction of Necroptosis

Xun Hu, Weidong Han and Ling Li

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Targeting the “weak point” of cancers, especially the apoptotic/drug resistant cancers, is critical for the success of cancer chemotherapy. We found that the drug-resistant cancer cell lines overexpressing P-gp, MRP1, BCRP, Bcl-2, and Bcl-xL are susceptible to shikonin, a necroptotic inducer, despite the fact that they are highly resistant to a variety of anticancer agents such as anthracycline antibiotics, vinca alkaloids, taxanes, epipodophylotoxins, etc.. These findings reveal that, although apoptotic/drug resistance is a formidable “stronghold” of cancer against chemotherapy, necroptotic susceptibility is an intrinsic “weak point” of cancer. Therefore, targeting the weakness of cancer by induction of necroptosis may have significant potential in cancer chemotherapy, especially in the apoptotic/drug resistant cancers.

Addendum to:
Shikonin Circumvents Cancer Drug Resistance by Induction of a Necroptotic Death
W. Han, L. Li, S. Qiu, Q. Lu, Q. Pan, Y. Gu, J. Luo and X. Hu
Mol Cancer Ther 2007; 6:1641-9

Authors

Xun Hu

Zhejiang University School of Medicine

Weidong Han

Zhejiang University

Ling Li

Zhejiang University

This is an open-access article

 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.