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Article Addendum
Cathepsin D Deficiency and NCL/Batten Disease: There’s More to Death than Apoptosis
John J. Shacka and Kevin A. Roth
volume 3 | issue 5
September/October 2007Pages: 474 - 476
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Animal models of cathepsin D (CD) deficiency are characterized by a progressive and relentless neurodegenerative phenotype similar to that observed in Neuronal Ceroid Lipofuscinoses (NCL), a group of pediatric neurodegenerative diseases known collectively as Batten Disease. We have shown recently that the targeted deletion of the pro-apoptotic molecule Bax prevents apoptotic markers but not neuron death and neurodegeneration induced by CD deficiency, which suggests that alterations in the macroautophagy-lysosomal degradation pathway can mediate neuron death in NCL/Batten Disease in the absence of apoptosis. Herein, we review CD deficiency in the broader context of NCL and offer potential mechanisms for neuron death and neurodegeneration induced by CD deficiency.
Addendum to:
Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent Apoptosis
J.J. Shacka, B.J. Klocke, C. Young, M. Shibata, J.W. Olney, Y. Uchiyama, P. Saftig and K.A. Roth
J Neurosci 2007; 27:2081-90
Authors
John J. Shacka
University of Alabama at Birmingham
Kevin A. Roth
University of Alabama at Birmingham
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.