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Article Addendum
AMPK Mediates Autophagy during Myocardial Ischemia In Vivo
Hiromitsu Takagi, Yutaka Matsui, Shinichi Hirotani, Hideyuki Sakoda, Tomoichiro Asano and Junichi Sadoshima
volume 3 | issue 4
July/August 2007Pages: 405 - 407
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We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.
Addendum to:
Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy
Y. Matsui, H. Takagi, X. Qu, M. Abdellatif, H. Sakoda, T. Asano, B. Levine and J. Sadoshima
Circ Res 2007; 100:914-22
Authors
Hiromitsu Takagi
University of Medicine and Dentistry of New Jersey
Yutaka Matsui
University of Medicine and Dentistry of New Jersey
Shinichi Hirotani
University of Medicine and Dentistry of New Jersey
Hideyuki Sakoda
University of Tokyo
Tomoichiro Asano
Hiroshima University
Junichi Sadoshima
University of Medicine and Dentistry of New Jersey
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.