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Article Addendum
Autophagy Induction and Autophagic Cell Death in Effector T Cells
Binfeng Lu, Elizabeth Capan and Changyou Li
volume 3 | issue 2
March/April 2007Pages: 158 - 159
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The population size of the T cells is tightly regulated. The T cell number drastically increases in response to their specific antigens. Upon antigen clearance, the T cell number decreases over time. Apoptosis, also called type I programmed cell death, plays an important role in eliminating T cells. The role of autophagic cell death, also called type II programmed cell death, is unclear in T cells. Our recent work demonstrated that autophagy is induced in both Th1 and Th2 cells. Both TCR signaling and IL-2 increase autophagy in T cells, and JNK MAP kinases are required for the induction of autophagy in T cells, whereas caspases and mTOR inhibit autophagy in T cells. Autophagy is required for mediating growth factor withdrawal-dependent cell death in T cells. Here, we hypothesize that autophagic cell death plays an important role in T cell homeostasis.
Addendum to:
Autophagy is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death
C. Li, E. Capan, Y. Zhao, J. Zhao, D. Stolz, S.C. Watkins, S. Jin and B. Lu
J Immunol 2006; 177:5163-8
Authors
Binfeng Lu
University of Pittsburgh
Elizabeth Capan
University of Pittsburgh
Changyou Li
University of Pittsburgh
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.