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Article Addendum
Permeases Recycle Amino Acids Resulting from Autophagy
Zhifen Yang and Daniel J. Klionsky
volume 3 | issue 2
March/April 2007Pages: 149 - 150
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Autophagy is a major survival mechanism for eukaryotes to recycle cellular nutrients during stress conditions (such as nutrient limitation, or the accumulation of damaged organelles). We recently revealed a molecular mechanism by which Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Atg22 is not directly required for autophagic body breakdown, in contrast to previously reported data. Instead, we found that Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxers, which mediate the efflux of leucine and other amino acids resulting from autophagy.
Addendum to:
Atg22 Recycles Amino Acids to Link the Degradative and Recycling Functions of Autophagy
Zhifen Yang, Ju Huang, Jiefei Geng, Usha Nair and Daniel J. Klionsky
Mol Biol Cell 2006; Oct. 4
Authors
Zhifen Yang
University of Michigan
Daniel J. Klionsky
Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, and Department of Biological Chemistry; University of Michigan; Ann Arbor, Michigan USA
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.