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Article Addendum
A smARF Way to Die: A Novel Short Isoform of p19ARF is Linked to Autophagic Cell Death
Sharon Reef and Adi Kimchi
volume 2 | issue 4
October/November/December 2006Pages: 324 - 326
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
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We recently revealed a novel mechanism by which p19ARF can induce cell death. We found that the p19ARF mRNA encodes an additional shorter isoform from the same open reading frame, named smARF. smARF is a short lived protein, which is rapidly degraded by the proteasome, but accumulates after inappropriate proliferative signals generated by oncogenes. Surprisingly, smARF translocates to the mitochondria, impairs the structure of the mitochondria and dissipates the mitochondrial membrane potential in a p53 and Bcl-2 family independent manner, ultimately inducing type II caspase-independent autophagic cell death.
Addendum to:
A Short Mitochondrial form of p19(ARF) Induces Autophagy and Caspase-Independent Cell Death
S. Reef, E. Zalckvar, O. Shifman, S. Bialik, H. Sabanay, M. Oren and A. Kimchi
Mol Cell 2006; 22:463-75
We now provide open access to journal articles published online for one year or more. This article may be downloaded at the following link:
Download PDF If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.