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Autophagy in Immune Defense Against Mycobacterium tuberculosis

Isabelle Vergne, Sudha Singh, Esteban Roberts, George Kyei, Sharon Master, James Harris, Sergio de Haro, John Naylor, Alex Davis, Monica Delgado, and Vojo Deretic

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Autophagy is a newly recognized innate and adaptive immunity defense against intracellular pathogens, in keeping with its role as a cytoplasmic maintenance pathway. Induction of autophagy by physiological, pharmacological or immunological means can eliminate intracellular Mycobacterium tuberculosis, providing one of the first examples of the immunological role of autophagy. Under normal circumstances, M. tuberculosis survives in macrophages by inhibiting phagolysosome biogenesis. Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative, compartments, where they are eliminated.

Authors

Isabelle Vergne

Sudha Singh

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