Autophagy vitalizes the pathogenicity of pathogenic fungi
Volume 8, Issue 10
Purchase or Subscribe
Pages 1415 - 1425http://dx.doi.org/10.4161/auto.21274
: appressorium, autophagy, autophagy-related (ATG
) genes, infection structure, pathogenicity
Authors: Xiao-Hong Liu, Hui-Min Gao, Fei Xu, Jian-Ping Lu, Rodney J. Devenish and Fu-Cheng Lin View affiliations
Plant pathogenic fungi utilize a series of complex infection structures, in particular the appressorium, to gain entry to and colonize plant tissue. As a consequence of the accumulation of huge quantities of glycerol in the cell the appressorium generates immense intracellular turgor pressure allowing the penetration peg of the appressorium to penetrate the leaf cuticle. Autophagic processes are ubiquitous in eukaryotic cells and facilitate the bulk degradation of macromolecules and organelles. The study of autophagic processes has been extended from the model yeast Saccharomyces cerevisiae to pathogenic fungi such as the rice blast fungus Magnaporthe oryzae. Significantly, null mutants for the expression of M. oryzae autophagy gene homologs lose their pathogenicity for infection of host plants. Clarification of the functions and network of interactions between the proteins expressed by M. oryzae autophagy genes will lead to a better understanding of the role of autophagy in fungal pathogenesis and help in the development of new strategies for disease control.
Received: February 1, 2012; Accepted: June 26, 2012; Published Online: August 30, 2012
Full Text - Ahead of Print Available - Log in!