The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts
Volume 8, Issue 10
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Pages 1537 - 1539http://dx.doi.org/10.4161/auto.21270
: G2019S, LRRK2, MAPK1/3, Parkinson disease, autophagy
Authors: José M. Bravo-San Pedro, Rubén Gómez-Sánchez, Mireia Niso-Santano, Elisa Pizarro-Estrella, Ana Aiastui-Pujana, Ana Gorostidi, Vicente Climent, Rakel López de Maturana, Rosario Sanchez-Pernaute, Adolfo López de Munain, José M. Fuentes and Rosa A. González-Polo View affiliations
The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LRRK2) gene is related to PD and its implication in autophagy regulation has been described. Our recent work shows that the presence of the G2019S LRRK2 mutation, one of the most prevalent in LRRK2, is accompanied by a deregulation of autophagy basal levels dependent on the MAPK1/3 (ERK2/1) pathway.
Autophagic Punctum to:
JM Bravo-San Pedro, M Niso-Santano, R Gomez-Sanchez, A Aiastui-Pujana, A Gorostidi, V Climent, et al. The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway. Cell Mol Life Sci 2012;
Received: June 19, 2012; Accepted: June 26, 2012; Published Online: August 23, 2012
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