Review
Autophagy in immunity: Implications in etiology of autoimmune/autoinflammatory diseases
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Pages 1286 - 1299
http://dx.doi.org/10.4161/auto.21212
Keywords: autoimmune disease, autoinflammatory disease, autophagy, immunity
Authors: Xu-Jie Zhou and Hong Zhang
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Abstract:
Autophagy is now emerging as a spotlight in trafficking events that activate innate and adaptive immunity. It facilitates innate pathogen detection and antigen presentation, as well as pathogen clearance and lymphocyte homeostasis. In this review, we first summarize new insights into its functions in immunity, which underlie its associations with autoimmunity. As some lines of evidence are emerging to support its role in autoimmune and autoinflammatory diseases, we further discuss whether and how it affects autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus and multiple sclerosis, as well as autoinflammatory diseases, such as Crohn disease and vitiligo.
Received: April 4, 2012; Accepted: June 21, 2012; Published Online: August 14, 2012
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