ER stress and autophagy contribute to CsA-induced death of malignant glioma cells
Volume 8, Issue 10
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Pages 1526 - 1528http://dx.doi.org/10.4161/auto.21155
: ER stress, autophagy, cyclosporine A, glioma, mTOR kinase
Authors: Iwona Anna Ciechomska and Bozena Kaminska View affiliations
Cyclosporine A (CsA), which revolutionized transplantology due to its ability to block the activation of lymphocytes and other immune system cells, triggers autophagy in malignant glioma cell lines via stimulation of endoplasmic reticulum (ER) stress. We also found that autophagy serves as a protective mechanism against CsA toxicity.
Autophagic Punctum to:
IA Ciechomska, K Gabrusiewicz, AA Szczepankiewicz, B Kaminska. Endoplasmic reticulum stress triggers autophagy in malignant glioma cells undergoing cyclosporine A-induced cell death. Oncogene 2012;
PMID: 22580614 DOI: 10.1038/onc.2012.174
Received: June 6, 2012; Accepted: June 18, 2012; Published Online: August 22, 2012
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