Autophagic Punctum
Autophagy defects in Lafora disease: Cause or consequence?
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Pages 289 - 290
http://dx.doi.org/10.4161/auto.8.2.19010
Keywords: endosomal defects, Epilepsy, intracellular amyloid-β deposits, neurodegenerative disorder, polyglucosan inclusion
Authors: Rajat Puri and Subramaniam Ganesh
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Abstract:
Lafora disease (LD) is an inherited and fatal form of neurodegenerative disorder characterized by the presence of an abnormal form of glycogen inclusions, called Lafora bodies, in neurons and other tissues. While Lafora bodies have been thought to underlie the neuropathology in LD, the specific process by which these inclusions might affect the neuronal functions was not very well understood. Here we review one of our recent studies on the LD animal model, wherein we have shown that the Lafora bodies might contribute to the impairment in the endosomal–lysosomal and autophagy pathways.
Autophagic Punctum to:
R Puri, T Suzuki, K Yamakawa, S Ganesh. Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease. Hum Mol Genet 2012; 21: 175-84
PMID: 21965301 DOI: 10.1093/hmg/ddr452
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