Autophagic Punctum

A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation

Volume 7, Issue 11   November 2011
Pages 1392 - 1393
http://dx.doi.org/10.4161/auto.7.11.17347
Authors: Svetlana Dokudovskaya and Michael P. Rout

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Abstract:
We now seem to live in a small world, in which everyone is highly interconnected. Cells, too, often also display tremendous interconnectivities in their component systems. As a recent case in point, we have identified a conserved protein complex—the SEA complex—that links the nuclear pore complex (NPC), the COPII vesicle coating complex, vacuoles and autophagy. In this punctum we will discuss the properties of this novel complex.

Autophagic Punctum to:
S Dokudovskaya, F Waharte, A Schlessinger, U Pieper, DP Devos, IM Cristea, R Williams, J Salamero, BT Chait, A Sali, MC Field, MP Rout, C Dargemont. A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics ;
PMID: 21454883 DOI: 10.1074/mcp.M110.006

Received: July 5, 2011; Accepted: July 20, 2011

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