Autophagic Punctum

The beta identity of class I PtdIns3K: A positive role of p110β in autophagy revealed

Volume 7, Issue 2   February 2011
Pages 246 - 247
http://dx.doi.org/10.4161/auto.7.2.14346
Authors: Zhixun Dou, Ji-An Pan, Richard Z. Lin and Wei-Xing Zong

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Abstract:
Autophagy is critically controlled by phosphatidylinositol 3-kinases (PtdIns3Ks). The common understanding for mammalian autophagy is that class I PtdIns3Ks inhibit autophagy by activating the Akt-TOR kinase cascade, whereas the class III PtdIns3K (Vps34) promotes autophagy by generating the phospholipid PtdIns(3)P. However, direct genetic evidence for a role of class I PtdIns3Ks in autophagy has been lacking. Using mice with a conditional deletion of the class I PtdIns3K catalytic subunit isoform p110α or p110β, we revealed an unexpected function of p110β as a positive regulator of autophagy.

Autophagic Punctum to:
Z Dou, M Chattopadhyay, JA Pan, JL Guerriero, YP Jiang, LM Ballou, Z Yue, RZ Lin, WX Zong. The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. J Cell Biol 2010; 191: 827-43
PMID: 21059846 DOI: 10.1083/jcb.20100605

Received: November 29, 2010; Accepted: December 2, 2010

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