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Autophagic Punctum

IKK connects autophagy to major stress pathways

Alfredo Criollo, Laura Senovilla, Hélène Authier, Maria Chiara Maiuri, Eugenia Morselli, Ilio Vitale, Oliver Kepp, Ezgi Tasdemir, Lorenzo Galluzzi, Shensi Shen, Maximilien Tailler, Nicolas Delahaye, Antoine Tesniere, Daniela De Stefano, Aména Ben Younes, Francis Harper, Gérard Pierron, Sergio Lavandero, Laurence Zitvogel, Alain Israel, Véronique Baud and Guido Kroemer

Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFκB is perhaps the transcription factor most frequently activated by stress, and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IκB kinase) complex, which is critical for the stress-elicited activation of NF-κB, is sufficient to promote autophagy independent of NFκB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.

Punctum to: Criollo A, Senovilla L, Authier H, Maiuri MC, Morselli E, Vitale I, Kepp O, Tasdemir E, Galluzzi L, Shen S, Tailler M, Delahaye N, Tesniere A, De Stefano D, Younes AB, Harper F, Pierron G, Lavandero S, Zitvogel L, Israel A, Baud V, Kroemer G. The IKK complex contributes to the induction of autophagy. EMBO J 2009; In press.

Authors

Alfredo Criollo

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France; Faculty of Chemical and Pharmaceutical Sciences/Medicine; FONDAP Center CEMC; University of Chile; Santiago, Chile

Laura Senovilla

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Hélène Authier

Institut Cochin; Université Paris Descartes; CNRS; UMR 8104; Paris, France

Maria Chiara Maiuri

INSERM; U848; Institut Gustave Roussy; Université Paris-Sud; Villejuif, France; Università degli Studi di Napoli Federico II; Facoltà di Scienze Biotecnologiche; Napoli, Italy

Eugenia Morselli

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Ilio Vitale

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Oliver Kepp

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Ezgi Tasdemir

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Lorenzo Galluzzi

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Shensi Shen

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Maximilien Tailler

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Nicolas Delahaye

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; INSERM; U805; Villejuif, France

Antoine Tesniere

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Daniela De Stefano

Dipartimento di Farmacologia Sperimentale; Università degli Studi di Napoli Federico II; Napoli, Italy

Aména Ben Younes

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; Université Paris Sud-Paris 11; Villejuif, France

Francis Harper

CNRS; FRE 2937; Institut André Lwoff; Villejuif, France

Gérard Pierron

CNRS; FRE 2937; Institut André Lwoff; Villejuif, France

Sergio Lavandero

Faculty of Chemical and Pharmaceutical Sciences/Medicine; FONDAP Center CEMC; University of Chile; Santiago, Chile

Laurence Zitvogel

INSERM; U848; Villejuif, France; Institut Gustave Roussy; Villejuif, France; INSERM; U805; Villejuif, France

Alain Israel

CNRS URA 2582; Institut Pasteur; Paris, France

Véronique Baud

Guido Kroemer Corresponding author: kroemer@igr.fr