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Artophagosome

Artophagy: The Art of Autophagy-the Cvt pathway

David S. Goodsell and Daniel J. Klionsky

Science informs art, and art informs science. Both processes involve creativity and imagination, and collaboration between scientists and artists often leads to new insights in both fields. We took advantage of the power of artistic imagery to demonstrate a dynamic cellular process, autophagy. In particular, we depicted the cytoplasm to vacuole targeting pathway, which involves dynamic membrane rearrangements to sequester a specific cargo via an autophagy-related process. By depicting this event in the context of a crowded cellular milieu, we hoped to stimulate researchers to consider aspects of the process that might be overlooked in the overly simplistic schematic drawing that typify most scientific models.

Authors

David S. Goodsell Corresponding author: goodsell@scripps.edu

The Scripps Research Institute; La Jolla, CA USA

Daniel J. Klionsky Corresponding author: klionsky@umich.edu

Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, and Department of Biological Chemistry; University of Michigan; Ann Arbor, Michigan USA