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Autophagic Punctum

A role for chloride transport in lysosomal protein degradation

Lena Wartosch and Tobias Stauber
Volume 6, Issue 1
January 1, 2010
Pages 158 - 159

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Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed protein is slowed down and accumulation of autophagosomes occurs.

Punctum to: Wartosch L, Fuhrmann JC, Schweizer M, Stauber T, Jentsch TJ. Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7. FASEB J 2009; In press; PMID: 19661288; DOI: 10.1096/fj.09-130880.


Authors

Lena Wartosch Corresponding author: Lena.wartosch@mdc-berlin.de
Max-Delbrück-Centrum für Molekulare Medizin (MDC) and Leibniz-Institut für Molekulare Pharmakologie (FMP); Berlin, Germany
Tobias Stauber
Max-Delbrück-Centrum für Molekulare Medizin (MDC) and Leibniz-Institut für Molekulare Pharmakologie (FMP); Berlin, Germany

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