• Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway
  • Symbiophagy and biomineralization in the “living fossil” <i>Astrosclera willeyana</i>
  • BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42
  • Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway

Shi-Hao Tan, Guanghou Shui, Jing Zhou, Yin Shi, Jingxiang Huang, Dajing Xia, Markus R Wenk and Han-Ming Shen

 Symbiophagy and biomineralization in the “living fossil” Astrosclera willeyana

Daniel J Jackson and Gert Wörheide

BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid β 42

Jihoon Nah, Jong-Ok Pyo, Sunmin Jung, Seung-Min Yoo, Tae-In Kam, JaeWoong Chang, Jonghee Han, Seong Soo A. An, Takashi Onodera and Yong-Keun Jung

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Obaid Aftab, Mårten Fryknäs, Xiaonan Zhang, Angelo De Milito, Ulf Hammerling, Stig Linder, Rolf Larsson and Mats G Gustafsson

Current Issue

Autophagy

August 2014

Volume 10, Issue 8

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About the cover image
The cover illustrates a pre-treatment (left) and on-treatment (right) fluorodeoxyglucose positron emission tomography (FDG-PET) scan of a metastatic melanoma patient treated on a phase I trial of the autophagy modulating drugs temsirolimus and hydroxychloroquine. Treatment associated metabolic compromise can be seen in the fdg-avid tumor on the chest wall. This is one over 200 human patients and dogs enrolled onto multiple phase I trials involving hydroxychloroquine which are reported in this issue. The cover images were provided by Ravi K Amaravadi.

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