Email this page Print this page

Conceptual Review

Aging: ROS or TOR

Mikhail V. Blagosklonny
Volume 7, Issue 21
November 1, 2008
Pages 3344 - 3354

This is an open-access article


 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.


It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.


Authors

Mikhail V. Blagosklonny
Ordway Research Institute; Albany, NY

This is an open-access article


 Download PDF

If the document does not open, please right-click on the link (control-click on a Macintosh) and select the option to save the file to disk.

Advertisements