Introduction The integrin a 1 subunit was first discovered .. by Hemler et al as the a component of the Very Late .. Antigen I (VLA1) expressed on a subset of T cells in the joints of patients .. with rheumatoid arthritis,1 as well as in a subset of lymphocytes after long .. term in vitro...

Glycodelin has many names in the literature, such as placental protein 14 (PP14), human ..placental organ-specific a2-globulin, or progesterone-dependent endometrial protein, based on electrophoretic characteristics, regulation, or tissue of first identification.1-4 After detailed information...

The development of several gene expression profiling methods, such as comparative ..genomic hybridization (CGH), differential display, serial analysis of gene expression ..(SAGE), and gene microarray, together with the sequencing of the human genome, has provided an opportunity to monitor and...

Human blood cell similar to embryonic and nerve cells can extend thin and very long exten-\r\n.sions having the same diameter along the entire length called cytonemes. Cytonemes were \r\n.shown to connect blood cells over a distance of several cell diameters and transport membrane proteins,...

After their initial discovery in the mid 1800s, neural crest cells transitioned from the ...category of renegade intra-embryonic wanderers to achieve rebel status, provoked espe-...cially by the outrageous claim that they participate in skeletogenesis, an embryonic event theretofore reserved...

Toxoplasma gondii infects a wide range of warm-blooded vertebrates including humans and is one of the world’s most successful parasites. As a member of the phylum Apicomplexa, T. gondii is a model for understanding infection by a variety of related parasites such as Plasmodium and...

Recent advances in molecular biology and microarray technology have opened the door ...for massively parallel analysis of transcriptional networks. The development of ...chromatin immunoprecipitation methods allows for the assessment of transcription factor to target binding in vivo, and powerful...

The dynamic remodeling of the actin cytoskeleton plays an essential role in many ....cellular processes, including cell motility, cytokinesis, and intracellular transport. A ....large number of actin-binding proteins (ABPs) participate in this process, regulating the assembly of actin filaments...

Hsp90 is an essential and ubiquitous molecular chaperone that is required for the proper..folding of a set of client proteins at a late stage in their folding process. In eukaryotes,..cytoplasmic Hsp90 is absolutely essential for cell viability under all growth conditions...The functional cycle...

The most abundant cytoplasmic chaperone of eukaryotic cells, Hsp90 is a hub..in developmental regulatory networks and the first example described of the..phenomenon of molecular buffering. As a chaperone for many different signaling..proteins, Hsp90 maintains the clarity and strength of...