The eukaryotic cell cycle is driven by an evolutionarily conserved engine consisting of a series of cyclin-dependent kinase (CDK)-cyclin modules. The orderly events of the cell cycle depend on the complex interplay of many factors, but the long-held idea that activation and inhibition of...

Cyclin-dependent kinases (CDKs) are essential regulators of the cell cycle and transcription . In the budding yeast Saccharomyces cerevisiae and the fission yeast Saccharomyces pombe , a single CDK (Cdc28p or its ortholog Cdc2, respectively) catalyzes all major cell cycle transitions. 1,2...

Activation of cyclin dependent kinases (CDKs) by phosphorylation of the conserved Tloop is a regulatory step of cell cycle progression that was discovered just a decade ago. A wealth of data regarding this activation and of potential CDK activating kinases (CAKs) has accumulated. Despite this...

Recent development in plant molecular genetics has facilitated our understanding of how plants accomplish their body plans in response to various environmental signals. Plants have a unique feature of making almost all organs after embryogenesis, and morphogenesis usually takes place at a...

The eukaryotic cell division cycle is controlled via the sequential activation and inactivation of cyclin-dependent protein kinases (cdks). In the budding yeast Saccharomyces cerevisiae , Cdc28p is the only CDK involved in regulating the cell cycle, while in higher eukaryotes, multiple CDKs...

Activation of cyclin dependent kinases (CDKs) by phosphorylation of the conserved Tloop is a regulatory step of cell cycle progression that was discovered just a decade ago. A wealth of data regarding this activation and of potential CDK activating kinases (CAKs) has accumulated. Despite this...

TFIIH was originally identified as a basal transcription factor involved in protein-coding genes transcription. The systematic cloning of its nine subunits revealed however that TFIIH also participates in two other fundamental cell processes: cell cycle regulation and repair of damaged DNA....

Sequential activation of members of the cyclin-dependent kinase (CDK) family orders the events required for DNA replication and cell division. Both the CDK and cyclin families have multiple members that selectively bind to preferred partners to generate complexes that drive cell cycle...