With the advent of high throughput transcriptomics came the realization that large swathes of the un‑annotated genome variously referred to as “junk DNA”, “selfish DNA” or “gene deserts,” produce vast numbers of transcripts with low or no protein‑coding potential, that have heretofore eluded detection or description. Indeed, there is now virtual consensus that transcription from the majority of the genome in complex organisms gives rise to this novel class of molecules. Long non‑coding RNAs (lncRNAs) range in size from 200 to several thousand nucleotides and mediate critical cellular functions, including transcriptional and post‑transcriptional regulation, subcellular trafficking and organelle biogenesis. It is therefore not surprising that recent studies have implicated their aberrant expression in behaviors that contribute to disease, including metastasis. Approximately 1.5 million women worldwide are diagnosed with breast cancer annually, many of whom will have occult disseminated tumor cells at first diagnosis (http://www.worldwidebreastcancer.com). Despite significant improvements in early diagnosis and treatment, these metastatic outgrowths will progress to clinically relevant and life threatening lesions in about 20% of patients. The molecular mechanisms underlying dissemination of tumor cells to distant organs remain poorly understood but are likely to include a significant regulatory role for lncRNA.