The concept of organotropism is by no means novel; for over a century it has been observed that certain primary tumor types have a tendency to metastasize to specific secondary sites. Yet it is only since the dawn of the 21st century that genomics has emerged as a valuable tool for probing the mysteries behind what drives organotropism. Metastasis is a complicated process involving many steps: intravasation, survival in circulation, extravasation, and colonization and growth at a distant site. The multi‑step nature of metastasis and the inherent complications associated with cancer cells make finding and studying the genes associated with organotropism difficult. However, in recent years, great strides have been made in the field of organotropism and metastasis. Here we examine some specific examples of genes associated with organotropism, along with the complicated processes involved with the regulation of metastatic tumor growth.