MSK1 and Nuclear Receptors Signaling

Chapter Details

Pub Date: 10 Dec 2013
Pages: 13
Chapter Category: Signal Transduction
Taken from the Book: MSKs
Book Series: Intelligence Unit
Edited by: J. Simon C. Arthur

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MSK1 and Nuclear Receptors Signaling

Aleksandr Piskunov and Cécile Rochette-Egly

About this Chapter

Nuclear receptors for steroid and non‑steroid hormones act through both genomic and non‑genomic mechanisms. Genomic events involve binding to cognate specific DNA sequences and subsequent recruitment of a battery of coregulators at the promoter. Non‑genomic events involve the rapid activation of kinase cascades and steroid as well as non‑steroid hormones trigger NR‑mediated activation of the MAPK/MSK1 pathway. Here we review the recent insights concerning the crosstalk between the genomic and non‑genomic actions of NRs, focusing on the mechanisms of MSK1 activation and influence on NR‑target genes transcriptional regulation.

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