From Structure to Function of RNA Binding Domains

Chapter Details

Pub Date: 10 Aug 2012
Pages: 22
Chapter Category: RNA
Taken from the Book: RNA Binding Proteins
Book Series: Intelligence Unit
Edited by: Zdravko J. Lorković

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From Structure to Function of RNA Binding Domains

Antoine Cléry and Frédéric H.-T. Allain

About this Chapter

RNA binding proteins (RBPs) are involved in each step of RNA metabolism. Most of them are composed of small RNA binding domains (RBDs) that are needed for their recruitment to specific RNA targets. The mode of RNA recognition of these RBDs has been studied by structural biologists for more than 20 years and seems to be highly versatile. In this chapter we review the current structural knowledge about RNA recognition by the four main RBD families, namely RNA recognition motifs (RRMs), zinc fingers, KH domains and double‑stranded RNA binding motifs (dsRBMs) detailing how structural data have brought information essential for a better understanding of RBP functions.


 

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