Harold S. Ginsberg
With the discovery of antibiotics during World War II, the use of tissue culture soon became relatively easy after the war had ended. These findings led to the discovery of many new viruses. One of these, as described in chapter 1, was adenoviruses, in 19531 and 1954. During the period since World War II, one has only to compare the books on virology that T. Rivers and F. Horsfall edited in 1959, and that B. Fields et al edited in 1996, to understand the number of viruses discovered during this period. Since the time of their discovery, 49 different types have been isolated from patients, and the diseases they induce are multiple (Table 25.1). Serum neutralization titers indicate that there is some cross-reactivity with a few other adenoviruses, but that it is not excessive. Thus, with homolgous, type-specific sera, type 3 virus has a titer of 2048 and type 48 has a titer of only 16; type 30 has a titer of 512 and type 49 a titer of 16; type 44 has a titer of 64 and type 48 a titer of 4096; and type 46 has a titer of 32 and type 49 a titer of 2048. It is critical to note, however, that type 48 and 49 have restriction enzyme analysis different from each other and from all other adenovirus types.