Adenoviral Vectors for Vaccines
Bernard Klonjkowski, Caroline Denesvre, and Marc Eloit
Several viruses can be used for the development of vectors for vaccination purposes. The human adenovirus type 2 (Ad2) and 5 (Ad5) have been used most extensively because of the greater understanding of their genome and interaction with the host cells. Nevertheless, for vaccination purposes other human adenoviruses, Ad3, Ad4 and Ad7 have also been developed, mainly because they are either not neutralized or neutralized weakly by convalescent sera of recipients of Ad2/Ad5 inoculation, a feature which makes them good tools for boost injections. The use of human adenoviruses must also not overshadow the opportunity to use animal adenoviruses, which could show similar or complementary properties. Moreover, this approach can also be dedicated to the development of veterinary vaccines. Among animal adenoviruses, until now, bovine (BAV3), ovine and canine (CAV2) adenoviruses have been used as gene transfer vectors.