Adenovirus-Mediated Gene Transfer: Applications in Lipoprotein Research
Silvia Santamarina-Fojo and Marcelo J.A. Amar
In the last decade adenovirus-mediated in vivo gene transfer has been effectively utilized to enhance our understanding of the role that different apolipoproteins, enzymes, receptors and transfer proteins play in lipoprotein metabolism, as well as to identify potential candidate genes that modify the atherogenic lipid profile and modulate the development of atherosclerosis. The feasibility of using recombinant adenovirus for the transient correction of metabolic defects in different animal models of hyperlipidemia and atherosclerosis has been demonstrated. The field awaits the development of new adenovirus vectors that will permit safe, long term expression of a transgene at physiologic levels for human application.