Chapter Details

Pub Date: 22 Dec 2011
Pages: 10
Chapter Category: Cell Biology
Taken from the Book: Notch Signaling in Embryology and Cancer
Book Series: Special Books
Edited by: Jörg Reichrath and Sandra Reichrath

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Notch Signaling in Lung Development and Disease

Keli Xu, Nadeem Moghal and Sean E. Egan

About this Chapter

Notch signaling plays an essential role in development and homeostasis of multiple organs including the lung. Dysregulation of Notch signaling has been implicated in various lung diseases including lung cancer. Here we review functions of Notch signaling in coordinating events during lung development, such as early proximodistal fate generation and branching, airway epithelial cell fate specification, alveogenesis and pulmonary vascular development. We also discuss roles of Notch in chronic obstructive pulmonary disease, progressive pulmonary fibrosis, pulmonary arterial hypertension, asthma and lung cancer.

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