Cathepsin Proteases in <i>Toxoplasma Gondii</i>

Chapter Details

Pub Date: 7 Mar 2011
Pages: 13
Chapter Category: Infectious Disease
Taken from the Book: Cysteine Proteases of Pathogenic Organisms
Book Series: Special Books
Edited by: Mark W. Robinson and John P. Dalton

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Cathepsin Proteases in Toxoplasma Gondii

Zhicheng Dou and Vern B. Carruthers

About this Chapter

Cysteine proteases are important for the growth and survival of apicomplexan parasites that infect humans. The apicomplexan Toxoplasma gondii expresses five members of the C1 family of cysteine proteases, including one cathepsin L‑like (TgCPL), one cathepsin B‑like (TgCPB) and three cathepsin C‑like (TgCPC1, 2 and 3) proteases. Recent genetic, biochemical and structural studies reveal that cathepsins function in microneme and rhoptry protein maturation, host cell invasion, replication and nutrient acquisition. Here, we review the key features and roles of T. gondii cathepsins and discuss the therapeutic potential for specific inhibitor development.
 

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