Mast Cells and Immunoregulation/Immunomodulation

Chapter Details

Pub Date: 25 Mar 2011
Pages: 26
Chapter Category: Immunology
Taken from the Book: Mast Cell Biology: Contemporary and Emerging Topics
Book Series: Special Books
Edited by: Alasdair M. Gilfillan and Dean D. Metcalfe

Download PDF

All chapters PDFs are available for free under an Open Access license.

Mast Cells and Immunoregulation/Immunomodulation

Mindy Tsai, Michele Grimbaldeston and Stephen J. Galli

About this Chapter

Mast cells often represent one of the first cells of the immune system to interact with environmental antigens, invading pathogens or environmentally‑derived toxins. Mast cells also can undergo alterations in phenotype, anatomic distribution and numbers during innate or adaptive immune responses. In addition to their well‑known roles as effector cells during IgE‑ and antigen‑induced allergic reactions, mast cells can be activated by many other signals, including some that are derived directly from pathogens or which are generated during innate or adaptive immune responses. Mast cells also express many costimulatory molecules with immunoregulatory activities and can secrete many products that can positively or negatively regulate immune responses. In this chapter, we describe mouse models used for analyzing mast‑cell function in vivo and illustrate how such models have been used to identify positive or negative immunomodulatory roles for mast cells during specific innate or adaptive immune responses. We also briefly describe some of the mast‑cell functions, products and surface receptors that have the potential to permit mast cells to promote or suppress immune responses that can either enhance host defense or contribute to disease.

More chapters from the book

Mast cells are enigmatic cells that are recognized as critical components of our immune system. They are strategically localized at the host/environment inte...

Sphingosine‑1‑phosphate (S1P) plays important roles regulating functions of diverse biological systems, including the immune system. S1P affects immune c...

A calcium signal is essential for degranulation, generation of eicosanoids and optimal production of cytokines in mast cells in response to antigen and other...

Mast cells play a major role in allergy and anaphylaxis, as well as a protective role in immunity against bacteria and venoms (innate immunity) and T‑cell ...

Mast cells (MCs) were first described by Paul Ehrlich1 in his doctoral thesis. MCs have long been implicated in the pathogenesis of allergic reactions and ce...

Mast cells (MCs) were once considered only as effector cells in pathogenic IgE‑ and IgG‑mediated responses such as allergy. However, developments over th...

The multiple cell types that comprise the immune system provide an efficient defense system against invading pathogens and micro‑organisms. In general, imm...

Upon activation through high affinity IgE receptors (FcεRI), mast cells (MCs) can release up to 100% of their content of preformed mediators stored in cytop...

This chapter summarizes the evidence for localized signaling domains in mast cells and basophils, with a particular focus on the high affinity IgE receptor, ...

Mast cells often represent one of the first cells of the immune system to interact with environmental antigens, invading pathogens or environmentally‑deriv...

Proteases are the most abundant class of proteins produced by mast cells. Many of these are stored in membrane‑enclosed intracellular granules until libera...

Mast cells are derived from the hematopoietic progenitors found in bone marrow and spleen. Committed mast cell progenitors are rare in bone marrow suggesting...

Mast cells play an important role in the lung in both health and disease. Their primary role is to initiate an appropriate program of inflammation and repair...

In recent years, the field of mast cell biology has expanded well beyond the boundaries of atopic disorders and anaphylaxis, on which it has been historicall...