TRIM Proteins as RING Finger E3 Ubiquitin Ligases

Chapter Details

Pub Date: 14 Nov 2012
Pages: 11
Chapter Category: Protein
Taken from the Book: TRIM/RBCC Proteins
Book Series: Special Books
Edited by: Germana Meroni

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TRIM Proteins as RING Finger E3 Ubiquitin Ligases

Kazuhiro Ikeda and Satoshi Inoue

About this Chapter

The tripartite motif (TRIM) proteins harboring the RING finger, B‑box and coiled‑coil (RBCC) domain motifs form a large protein family. The members of this family are involved in various biological processes, including growth, differentiation, apoptosis and transcription and also in diseases and oncogenesis. Recent studies have revealed that TRIM proteins play key roles in innate antiviral immunity. An accumulating body of evidence has demonstrated that some TRIM proteins function as E3 ubiquitin ligases in specific ubiquitin‑mediated protein degradation pathways; however, the precise mechanisms underlying this function have not been fully elucidated. In this chapter, we focus on the TRIM family of proteins specially with regard to E3 ligase.

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