CD8 T‑Cell Memory Differentiation during Acute and Chronic Viral Infections

Chapter Details

Pub Date: 4 Jun 2010
Pages: 17
Taken from the Book: Memory T Cells
Book Series: Special Books
Edited by: Maurizio Zanetti and Stephen P. Schoenberger

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CD8 T‑Cell Memory Differentiation during Acute and Chronic Viral Infections

Vandana Kalia, Surojit Sarkar and Rafi Ahmed

About this Chapter

CD8 T‑cell responses play an important role in protection against intracellular pathogens. Memory CD8 T cells mediate rapid clearance of pathogens upon secondary infection owing to their elevated frequency, ready localization to peripheral sites of infection and their ability to rapidly expand and mount effector functions. Such potent long‑lasting protective memory CD8 T cells develop in acute infections where antigen is effectively cleared. In contrast, chronic infections with persistently high viral loads are characterized by CD8 T‑cell dysfunction. In this chapter we present our current understanding of signals and mechanisms that regulate the development of functional long‑lived memory CD8 T cells during acute infections. This is discussed in the context of proposed models of memory differentiation and compared with CD8 T‑cell exhaustion and altered T‑cell homeostasis, as occurs during persistent viral infections.

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