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From the book Insect Nicotinic Acetylcholine Receptors
Diversity of Insect Nicotinic Acetylcholine Receptor Subunits
Andrew K. Jones and David B. Sattelle
- ISBN: 978-1-4419-6444-1
- Publication date: May 15, 2010
- Series: Intelligence Unit
Insect Nicotinic Acetylcholine Receptors
Edited by: Steeve Herve Thany
More chapters from the book:
Nicotinic acetylcholine receptors (nAChRs) are ligand‑gated ion channels that mediate fast synaptic transmission in the insect nervous system and are targets of a major group of insecticides, the neonicotinoids. They consist of five subunits arranged around a central ion channel. Since the...
Characterisation of Insect Nicotinic Acetylcholine Receptors by Heterologous Expression
Neil Millar and Stuart J. LansdellAs with other neurotransmitter receptors and ion channels, characterisation of nicotinic acetylcholine receptors (nAChRs) has relied heavily on studies conducted with cloned receptors expressed in artificial expression systems. Although much has been achieved in recent years by such studies,...
State of the Art on Insect Nicotinic Acetylcholine Receptor Function in Learning and Memory
Monique GauthierAcetylcholine is the most abundant excitatory neurotransmitter in the insect brain and the most numerous acetylcholine receptors are the nicotinic ones (nAChRs). The genome sequencing of diverse insect species has demonstrated the existence of at least 10 nAChR genes coding for α and β...
Fast, ionotropic neurotransmission mediated by ligand‑gated ion channels is essential for timely behavioral responses in multicellular organisms. Metazoa employ more ionotropic neurotransmitters in more types of synapses, inhibitory or excitatory, than is generally appreciated. It is becoming...
This paper reviews the available data on the toxicity of neonicotinoid insecticides to bees that are the prominent and the most economically important group of pollinators worldwide. Classical and new methods developed to take into account the characteristics and different types of effects of the...
Identification of Critical Elements Determining Toxins and Insecticides Affinity, Ligand Binding Domains and Channel Properties
Hélène Tricoire–Leignel and Steeve H. ThanyInsect nicotinic acetylcholine receptors have been objects of attention since the discovery of neonicotinoid insecticides. Mutagenesis studies have revealed that, although the detailed subunit composition of insect nicotinic acetylcholine receptors subtypes eludes us, the framework provided by...
Electrophysiological Studies and Pharmacological Properties of Insect Native Nicotinic Acetylcholine Receptors
Steeve Herve ThanyThe existence of several nicotinic acetylcholine receptor genes in insects suggests that many nicotinic receptor subtypes are present, but the identification and characterization of these subtypes in native neurons has been limited. Their pharmacological properties came from electrophysiological...
Identification of Cholinergic Synaptic Transmission in the Insect Nervous System
Steeve Thany, Hélène Tricoire–Leignel and Bruno LapiedA major criteria initially used to localize cholinergic neuronal elements in nervous systems tissues that involve acetylcholine (ACh) as neurotransmitter is mainly based on immunochemical studies using choline acetyltransferase (ChAT), an enzyme which catalyzes ACh biosynthesis and the ACh...
The use of neonicotinoid insecticides has grown considerably since their introduction in 1990s. They are used extensively for the control of agriculturally important crop pests and also in the control of cat and dog fleas. Imidacloprid exploited through an elaborated structural and substituent...
