The “O“ Class: Crafting Clinical Care with FoxO Transcription Factors

Chapter Details

Pub Date: 2 Nov 2009
Pages: 19
Chapter Category: Protein
Taken from the Book: Forkhead Transcription Factors: Vital Elements in Biology and Medicine
Book Series: Special Books
Edited by: Kenneth Maiese

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The “O“ Class: Crafting Clinical Care with FoxO Transcription Factors

Kenneth Maiese, Zhao Zhong Chong, Jinling Hou and Yan Chen Shang

About this Chapter

Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in both cellular physiology as well as clinical medicine. Internationally recognized investigators provide their insights and perspectives for a number of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders that can involve aging, cancer, cardiac function, neurovascular integrity, fertility, stem cell differentiation, cellular metabolism, and immune system regulation. Yet, the work clearly sets a precedent for the necessity to understand the cellular and molecular function of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the cellular environment.

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