Chemokine Binding Proteins Encoded by Pathogens

Chapter Details

Pub Date: 19 Oct 2009
Pages: 13
Chapter Category: Immunology
Taken from the Book: Pathogen-Derived Immunomodulatory Molecules
Book Series: Special Books
Edited by: Padraic Fallon

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Chemokine Binding Proteins Encoded by Pathogens

Antonio Alcami and Margarida Saraiva

About this Chapter

Chemokines are chemoattractant cytokines that play an important role in immunity. The role of chemokines against invading pathogens is emphasized by the expression of chemokine inhibitors by many pathogens. A mechanims employed by poxviruses and herpesviruses is the secretion of chemokine binding proteins unrelated to host receptors that bind chemokines with high affinity and block their activity. Soluble chemokine binding proteins have also been identified in the human parasite Schistosoma mansoni and in ticks. The binding specificity of these inhibitors of cell migration point at chemokines that contribute to host defense mechanisms against various pathogens. Chemokine binding proteins modulate the immune response and may lead to new therapeutic approaches to treat inflamatory diseases.

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