Adhesion‑Dependent Modulation of Macrophage K+ Channels

Chapter Details

Pub Date: 1 Apr 2010
Pages: 14
Chapter Category: Channels and Transporters
Taken from the Book: Integrins and Ion Channels: Molecular Complexes and Signaling
Book Series: Special Books
Edited by: Andrea Becchetti and Annarosa Arcangeli

Download PDF

All chapters PDFs are available for free under an Open Access license.

Adhesion‑Dependent Modulation of Macrophage K+ Channels

Margaret Colden-Stanfield

About this Chapter

Integrin‑mediated adhesion of monocytes not only triggers cell rolling and diapedesis, it also activates ionic permeability changes resulting in monocyte activation, maturation and differentiation. Mononuclear phagocytes possess voltage‑dependent inwardly rectifying K+ (Kir) currents and delayed outwardly, rectifying K+ (Kdr) currents that are modulated by tissue origin, adherence, presence of growth factors or cytokines and the functional or differentiation state of the cells. This chapter reviews the exploration of Kir and Kdr channels in mononuclear phagocytes over the last 30 years with an emphasis on culturing conditions, modulation by substrates and role in macrophage function. It has only been recent that successful attempts have been made to study these K+ currents in monocytes/macrophages as they may be engaged in the human body which may serve as the foundation for the development of novel therapeutic agents targeting macrophage Kir/Kdr channel activity to favorably influence risk factors for hypertension, atherosclerosis and diabetes.

More chapters from the book

Ion channels are integral membrane proteins that contain pathways through which ions can flow. By shifting between closed and open conformational states (‘gat...
Plastic expression of different integrin subunits controls the different stages of neural development, whereas in the adult integrins regulate synaptic stabilit...
A role for integrins in mechanotransduction has been suggested because these molecules form an important mechanical link between the extracellular matrix (ECM) ...
Cancer is a complex multistep disease characterized by a profound genetic instability which leads to the aberrant and uncoordinated expression of several gene p...
Physical and functional link between cell adhesion molecules and ion channels provide a rapid connection between extracellular environment and cell physiology. ...
Forster (or Fluorescence) resonance energy transfer (FRET) is a physical process in which energy is transformed nonradiatively from an excited fluorophore, serv...
Protein‑protein interactions between integrins and ion channels consist in a complicated bidirectional talk, not yet understood in detail, which triggers a do...
Integrin‑mediated adhesion of monocytes not only triggers cell rolling and diapedesis, it also activates ionic permeability changes resulting in monocyte acti...
Integrin signalling has a critical function in organizing cells in tissues during both embryonic development and tissue repair. Following their binding to the e...
Cell migration is necessary for proper embryonic development and adult tissue remodeling. Its mechanisms determine the physiopathology of processes such as neur...