The Role of the JAK/STAT Pathway in Inflammatory Bowel Diseases
Raja Atreya and Markus F. Neurath
Although the exact pathogenic mechanisms in inflammatory bowel diseases (IBD) still remain unclear, increasing evidence has implicated proinflammatory cytokines and their related transcription factors as crucial mediators of the inflammatory reaction. It has been shown that cytokine signaling pathways involving transcription factors of the signal transducers and activators of transcription (STAT) family play a key role in the immunpathogenesis of these diseases. Therefore novel therapeutic strategies aim at targeting these signal transduction pathways. Among these, different therapeutic approaches that interfere with the IL‑6/STAT‑3 trans signaling pathway in IBD have shown promising results in experimental models, as well as in clinical trials. In the following, current data concerning the pathogenic role of the JAK/STAT pathway in IBD is presented and possible therapeutic implications of targeting these pathways are discussed.