STAT1 and STAT3 in Tumorigenesis: Two Sides of the Same Coin?

Chapter Details

Pub Date: 11 Jun 2009
Pages: 22
Chapter Category: Cell Biology
Taken from the Book: JAK-STAT Pathway in Disease
Book Series: Intelligence Unit
Edited by: Anastasis Stephanou

Download PDF

All chapters PDFs are available for free under an Open Access license.

STAT1 and STAT3 in Tumorigenesis: Two Sides of the Same Coin?

Sara Pensa, Gabriella Regis, Daniela Boselli, Francesco Novelli and Valeria Poli

About this Chapter

The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis. While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is considered as an oncogene, STAT1 enhances inflammation and innate and adaptive immunity, triggering in most instances anti‑proliferative and pro‑apoptotic responses in tumor cells. Despite being activated downstream of common cytokine and growth factor receptors, their activation is reciprocally regulated and perturbation in their balanced expression or phosphorylation levels may redirect cytokine/growth factor signals from proliferative to apoptotic, or from inflammatory to anti‑inflammatory. Here we review the functional canonical and non canonical effects of STAT1 and STAT3 activation in tumorigenesis and their potential cross‑regulation mechanisms and discuss the hypothesis that perturbation of their expression and/or activation levels may provide novel cancer therapeutic strategies.

More chapters from the book

The seven members of the mammalian signal transducer and activator of transcription (STAT) family participate in a wide range of biological processes with impac...
The stability and commitment of T-helper cells is controlled by three factors; the cytokines present in the microenvironment, the acquisition and/or downregulat...
The JAK‑STAT (Janus Kinases‑Signal Transducers and Activators of Transcription) intracellular signal transduction pathway plays a critical role in many huma...
Suppressor of cytokine signaling (SOCS) proteins have been identified as key negative regulators of cytokine and growth factor signaling. Therefore, given the d...
As cancer continues to cause over 500,000 deaths per year in the United States alone, it is clear that the cytotoxic drugs commonly in use for cancer treatment ...
The transcription factors Stat5a and Stat5b are crucial gene regulators for all hematopoietic cell types. Stat5 proteins play essential roles in hematopoietic s...
The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis. While STAT3 promotes cell survival/proliferation, motility and immune ...
Although the exact pathogenic mechanisms in inflammatory bowel diseases (IBD) still remain unclear, increasing evidence has implicated proinflammatory cytokines...
Drosophila melanogaster is a developmentally and genetically highly tractable animal model and many significant advances in the field of signal transduction hav...
The signal transducers and activators of transcription (STATs) are a family of transcription factors which were originally identified on the basis of their abil...
The level of transcription factor activity critically regulates cell fate decisions such as hematopoietic stem cell self‑renewal and differentiation. The bala...
The STAT family of proteins is comprised of seven transcription factors that have diverse roles in tissue homeostasis, differentiation and immune function. The ...