Lipoxins as an Immune‑Escape Mechanism

Chapter Details

Pub Date: 19 Oct 2009
Pages: 10
Chapter Category: Immunology
Taken from the Book: Pathogen-Derived Immunomodulatory Molecules
Book Series: Special Books
Edited by: Padraic Fallon

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Lipoxins as an Immune‑Escape Mechanism

Fabiana S. Machado and Julio Aliberti

About this Chapter

Here, we discuss the mechanisms of repression of signaling pathways that are triggered by Lipoxin (LX) and are responsible for control of pro‑inflammatory response during chronic phase of Toxoplasma gondii infection. We also discuss this mechanism from the perspective of the pathogen, which pirates the host’s lipoxygenase machinery to its own advantage as a probable immune‑escape mechanism. Pro‑inflammatory mediators such as IL‑12, IFN‑γ and TNF are essential in controlling parasite growth during T. gondii infection. However, it is clear that exacerbated production of these cytokines results in host tissue damage. LX, an anti‑inflammatory eicosanoid, plays an important role in regulation of immune response to T. gondii.

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