PACSIN 1/syndapin 1 was originally identified by its drastic expression decrease during CNS repair processes and by virtue of its binding to the GTPase dynamin. The three family members play important roles as accessory proteins in clathrin‑mediated endocytosis. They differ in tissue...

S chizosaccharomyces pombe is a simple model organism ideal for study of conserved proteins of interest. The genome of S. pombe encodes seven proteins containing F‑BAR domains, including four scaffolding proteins of the pombe cdc15 homology (PCH) family and three Rho GTPase activating...

The F‑BAR family of proteins has emerged as important coordinators of signaling pathways that regulate actomyosin assembly and membrane dynamics. This review article will focus on the Cdc42‑interacting protein 4 (CIP4) family of proteins. Recently, they have been found to bind phospholipids...

NOSTRIN is a prototypic PCH/F‑BAR protein with an N‑terminal F‑BAR domain mediating membrane association and a C‑terminal SH3 domain representing a docking platform for various proteins. Human NOSTRIN has recently been shown to function as an adaptor protein in caveolar trafficking of...

FES and FER are the only two members of a distinct subgroup of the protein‑tyrosine kinase (PTK) family. What distinguishes them from other PTKs and indeed all other kinases, are their unique amino‑terminal domains, which contain sequences homologous to the recently solved F‑BAR domains of...

PSTPIP1 and PSTPIP2 are expressed predominantly in the hematopoietic system where their C‑terminal tyrosine phosphorylation is regulated by PEST family phosphatases. Both proteins deform membranes via their conserved F‑BAR domains and regulate actin organization, but their actin regulatory...

Proteins that belong to the BAR (Bin, Amphiphysin, RVS) domain superfamily are alpha‑helical bilayer‑binding modules that have evolved to induce or stabilize membrane curvature during cellular events like endocytosis, cell division and organelle biogenesis. Within the superfamily, a subset of...

The budding yeast Saccharomyces cerevisiae genome encodes two classical Pombe Cdc15 Homology (PCH) proteins: Hof1p (or Cyk2p) and Bzz1p (or Lsb7p). Like mammalian PCH proteins, both have an N‑terminal F‑BAR domain and C‑terminal Src Homology 3 (SH3) domain(s). The yeast genome also encodes...

Gas7 (growth‑arrest specific gene 7) has recently been classified to be a member of the Pombe Cdc 15 homology (PCH) family and belongs to the proline, serine, threonine‑rich phosphatase interacting protein (PSTPIP) subfamily.1,2 Most PCH proteins share a similar domain architecture, which is...