The CIP4 Family of F‑BAR Domain‑Containing Proteins
Marcia Toguchi and Pontus Aspenström
The F‑BAR family of proteins has emerged as important coordinators of signaling pathways that regulate actomyosin assembly and membrane dynamics. This review article will focus on the Cdc42‑interacting protein 4 (CIP4) family of proteins. Recently, they have been found to bind phospholipids and participate in membrane deformation by virtue of their F‑BAR domains. These findings suggest that CIP4 family are critical linkers of membrane dynamics and actin polymerization, for instance during the internalization of transmembrane receptors. Moreover, the CIP4 family has been linked to human diseases, such as Huntington’s disease, diabetes and cancer.