Lipid-Dependent Membrane Remodelling in Protein Trafficking
Priya P. Chandra and Nicholas T. Ktistakis
Trafficking pathways of eukaryotic cells exhibit sophisticated interplay between protein and lipid components. The protein molecules and their interacting networks are fairly well characterised. However, the lipid components and their regulation are much less understood. In this review, we describe our current understanding of how lipid dynamics can contribute to intracellular trafficking, based on evidence from genetic, biochemical and structural studies. We discuss issues concerning lipid heterogeneity and interconvertibility, and provide examples of how specific lipids can enable membrane remodelling in various transport steps.