Phylogenetic, Structural and Functional Relationships between WD‑ and Kelch‑Repeat Proteins

Chapter Details

Pub Date: 5 Aug 2008
Pages: 14
Chapter Category: Cell Biology
Taken from the Book: The Coronin Family of Proteins
Book Series: Special Books
Edited by: Christoph Clemen, Ludwig Eichinger and Vasily Rybakin

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Phylogenetic, Structural and Functional Relationships between WD‑ and Kelch‑Repeat Proteins

Andrew M. Hudson and Lynn Cooley

About this Chapter

The β‑propeller domain is a widespread protein organizational motif. Typically, β‑propeller proteins are encoded by repeated sequences where each repeat unit corresponds to a twisted β‑sheet structural motif; these β‑sheets are arranged in a circle around a central axis to generate the β‑propeller structure. Two superfamilies of β‑propeller proteins, the WD‑repeat and Kelch‑repeat families, exhibit similarities not only in structure, but, remarkably, also in the types of molecular functions they perform. While it is unlikely that WD and Kelch repeats evolved from a common ancestor, their evolution into diverse families of similar function may reflect the evolutionary advantages of the stable core β‑propeller fold. In this chapter, we examine the relationships between these two widespread protein families, emphasizing recently published work relating to the structure and function of both Kelch and WD‑repeat proteins.

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