Diversity of WD‑Repeat Proteins

Chapter Details

Pub Date: 5 Aug 2008
Pages: 11
Chapter Category: Cell Biology
Taken from the Book: The Coronin Family of Proteins
Book Series: Special Books
Edited by: Christoph Clemen, Ludwig Eichinger and Vasily Rybakin

Download PDF

All chapters PDFs are available for free under an Open Access license.

Diversity of WD‑Repeat Proteins

Temple F. Smith

About this Chapter

The WD‑repeat‑containing proteins form a very large family that is diverse in both its function and domain structure. Within all these proteins the WD‑repeat domains are thought to have two common features: the domain folds into a beta propeller; and the domains form a platform without any catalytic activity on which multiple protein complexes assemble reversibly. The fact that these proteins play such key roles in the formation of protein‑protein complexes in nearly all the major pathways and organelles unique to eukaryotic cells has two important implications. It supports both their ancient and proto eukaryotic origins and supports a likely association with many genetic diseases.

More chapters from the book

Most coronin proteins rely on interaction with actin in their functions. Mammalian coronin 7 has not been shown to interact with actin, but rather to bind to th...
The coronins, first described in Dictyostelium discoideum in 1991, have meanwhile been detected in all eukaryotes except plants. They belong to the superfamily ...
The WD‑repeat‑containing proteins form a very large family that is diverse in both its function and domain structure. Within all these proteins the WD‑rep...
What I’d like to do in this chapter is to share with you my recollections from the earliest days of coronin research and then to provide an overview of the st...
The β‑propeller domain is a widespread protein organizational motif. Typically, β‑propeller proteins are encoded by repeated sequences where each repeat u...
Coronins have maintained a high degree of conservation over the roughly 800 million years of eukaryotic evolution. From its origins as a single gene in simpler ...
Coronins are highly conserved among species, but their function is far from being understood in detail. Here we will introduce members of the family of coronin ...
This chapter discusses various aspects of coronin phylogeny, structure and function that are of specific interest. Two subfamilies of ancient coronins of unicel...
Coronin is a conserved actin binding protein that promotes cellular processes that rely on rapid remodeling of the actin cytoskeleton, including endocytosis and...
The WD repeat containing family of coronin proteins is generally referred to as F‑actin‑interacting proteins. While in lower eukaryotes such as Dictyosteliu...
The coronin gene family comprises seven vertebrate paralogs and at least five unclassified subfamilies in nonvertebrate metazoa, fungi and protozoa, but no repr...
Until recently, structural information about coronins was scarce and the earlier identification of five WD40 repeats gave rise to a structural prediction of a f...