4‑1BB as a Therapeutic Target for Human Disease

Chapter Details

Pub Date: 5 Jan 2009
Pages: 10
Chapter Category: Immunology
Taken from the Book: Therapeutic Targets of the TNF Superfamily
Book Series: Special Books
Edited by: Iqbal S. Grewal

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4‑1BB as a Therapeutic Target for Human Disease

Seung-Woo Lee and Michael Croft

About this Chapter

4‑1BB (CD137) is being thought of as an attractive target for immunotherapy of many human immune diseases based on encouraging results with 4‑1BB agonistic antibody treatment in mouse models of cancer, autoimmune disease, asthma and additionally as a means to improve vaccination. In this review, we will summarize the results of basic research on 4‑1BB and 4‑1BB immunotherapy of disease and provide some potential mechanistic insights into the many stimulatory and regulatory functions of 4‑1BB.

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