Annexin Gene Structure

Chapter Details

Pub Date: 1 Dec 1996
Pages: 14
Chapter Category: Cell Metabolism
Taken from the Book: Annexins: Molecular Structure to Cellular Function
Book Series: Intelligence Unit
Edited by: Barbara A. Seaton

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Annexin Gene Structure

Nicholas J. Nevid and Nelson D. Horseman

About this Chapter

The annexins comprise a relatively large family of calcium- and phospholipid-binding proteins. There are at least 10 distinct annexins in vertebrates (annexins I-VIII, XI and XIII), and additional members of this family have been identified in drosophila (annexins IX and X) and hydra (annexin XII). Annexins have been identified in other lower organisms, such as slime molds (annexin VII), sponges (annexin I) and sea urchins (annexin VI), and also in plants. New members of the annexin family will undoubtedly be discovered in the coming years. The annexins are defined structurally by a conserved C-terminal region that contains four or eight repeating units of about 70 amino acids each. These conserved repeats account for the shared abilities of annexins to bind both calcium and phospholipids, whereas specific functions of each annexin are determined by their type-specific N-terminal regions. These N-terminal regions differ in size, amino acid composition and posttranslational modification sites. Annexins are further regulated by alternative splicing and transcription.

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