Transcription Regulation in Spermatogenesis
Wing-Yee Lui and C. Yan Cheng
Spermatogenesis is a highly coordinated process in which diploid spermatogonia (2n) differentiate into mature haploid (1n) spermatozoa in the seminiferous epithelium. In this process, spermatogonia undergo several mitotic divisions and either enter a stem cell renewal pathway, or commit themsevles for further development. Diploid spermatocytes subsequently undergo two meiotic divisions and result in the production of haploid round spermatids. They then enter the process of spermiogenesis in which profound morphological and biochemical restructuring, such as the formation of acrosome and flagellum occur, and give rise to mature spermatozoa.