Chapter Category: BioMaterials

From the book Biomedical Applications of Polyurethanes

Biocompatibility of Polyurethanes

Yves Marois and Robert Guidoin

In the last 50 years, the development and the conception of biomaterials used for the construction of prostheses and medical devices has expanded very rapidly. A wide variety of biomaterials are now commonly implanted in the human body for the treatment of various diseases such as heart failure, atherosclerotic diseases, aortic aneurysm, ear dysfunction and cataracts. They are also used to augment tissue, namely, bone, muscle, skin and breast either after trauma or for cosmetic reasons. Biomaterials are the basic constituents of prostheses or implants which are designed to restore and support functions of organs and tissues as well as substitute and consolidate tissue, ligamentous, articular and osseous structures. They also can be used to stimulate the repair and healing of nerves, tissues and wounds in a precise and predetermined time frame or for a period of time exceeding the life expectancy of the recipient. The type of application, the organ function which needs to be restored, and the time of implantation are important factors dictating the choice between a material requiring long–term stability or one that will be bioresorbed. All biomaterials must meet a number of criteria and satisfy necessary requirements to comply with those of regulatory agencies for clinical use. The materials used in the design of prostheses and implants must be purified, constructed and sterilized using conventional methods. They should not contain impurities, initiators, additives, stabilizers, emulsifiers or coloring leachables that would cause in vivo reactions. This is further discussed in Chapter 3. rn

Taken from the book

Biomedical Applications of Polyurethanes

Edited by: Yves Marois and Robert Guidoin

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